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Nature Neuroscience (2010) doi:10.1038/nn.2562
Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
Nanna Goldman,Michael Chen,Takumi Fujita,Qiwu Xu,Weiguo Peng,Wei Liu,Tina K Jensen,Yong Pei,Fushun Wang,Xiaoning Han,Jiang-Fan Chen,Jurgen Schnermann,Takahiro Takano,Lane Bekar,Kim Tieu& Maiken Nedergaard
Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture.
止痛是针灸的一项常见功能，但过去人们对其科学原理并不十分清楚。美国一项最新研究认为，针灸可以促使机体释放一种天然止痛物质，从而起到止痛效果。
新一期英国《自然·神经科学》杂志刊登报告说，美国罗彻斯特大学等机构的研究人员通过动物实验发现了这一原理。他们对有一只爪子不舒服的实验鼠的相应膝盖部位进行约半小时的针灸，结果发现这会导致实验鼠机体释放一种名为腺苷的物质，这种物质具有天然的止痛效果，可以减轻实验鼠的疼痛。检测显示，针灸后相应部位腺苷的含量是针灸前的24倍以上。
为了进一步验证这项发现，研究人员还对实验鼠使用了一种使机体难以天然消除腺苷的药物。结果显示，使用这种药物后，机体中腺苷累积量明显增加，针灸止痛的有效时间延长到3倍以上。
参与这项研究的内德加德博士说，针灸治疗历史悠久，但由于其作用原理一直不太清楚，许多人对针灸持怀疑态度，而本次研究揭示了针灸止痛的确存在科学原理。 |
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楼主: zfj1028
发表于 2009-5-22 11:07:19
倒贴我都不要啊～
